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PDE4 inhibitors
PDE4 inhibitors
Phosphodiesterase 4 (PDE4) is an enzyme that degrades cyclic adenosine monophosphate (cAMP) to adenosine monophosphate (AMP), leading to the production of proinflammatory cytokines, which play a role in psoriasis pathogenesis. Inhibition of PDE4 blocks the degradation of cAMP and reduces inflammation.
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