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IL inhibitors
Interleukin (IL) pathways have been found to be involved in the immunopathogenesis of psoriasis. For example, IL-23 is a regulatory cytokine with a major role in the late-stage maturation and differentiation of T helper 17 lymphocytes, which are important in psoriatic inflammation. IL-23 has been found to be overexpressed in psoriatic lesions. Targeting these cytokines has demonstrated promise in the treatment of psoriasis and psoriatic arthritis.
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