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Deucravacitinib in patients with moderate-to-severe scalp psoriasis: Results from the phase IIIb/IV PSORIATYK SCALP trial
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The ongoing phase IIIb/IV multicenter, randomized, double-blind PSORIATYK SCALP trial (NCT05478499) is evaluating the safety and efficacy of deucravacitinib (n = 103), an oral, selective, allosteric TYK2 inhibitor, vs placebo (n = 47) in adult patients with moderate-to-severe scalp psoriasis.1 This trial includes patients with less extensive overall psoriasis (BSA involvement 3–10%) compared with the phase III POETYK PSO-1 and POETYK PSO-2 trials. Interim results were presented by Mark Lebwohl at the EADV 2024 Congress. 1 |
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The primary endpoint was met; at Week 16, ss-PGA 0/1 response rates were 48.5% in the deucravacitinib group vs 13.7% in the placebo group (p < 0.0001). Among patients with sPGA ≥3, ss-PGA 0/1 response rates in the deucravacitinib (n = 96) vs placebo groups (n = 47) were 50.0% vs 12.8% (p < 0.0001). |
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At Week 16, deucravacitinib when compared to placebo improved PSSI 90 response rates (38.8% vs 2.0%; p < 0.0001), CFB scalp-specific itch NRS (−3.2 vs −0.7; p < 0.0001), and sPGA 0/1 response rates in patients with sPGA ≥3 (51.0% vs 4.3%; p < 0.0001), BSA involvement 3–10% (42.9% vs 5.3%; p < 0.0001) and BSA involvement >10% (57.6% vs 0.0%; p = 0.0004). |
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Safety findings were consistent with the known profile of deucravacitinib, with no new signals observed. |
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Results from the PSORIATYK SCALP trial suggest that deucravacitinib is well tolerated and effective in patients with moderate-to-severe scalp psoriasis, including patients with less extensive overall body psoriasis. |
Abbreviations: BSA, body surface area; CFB, change from baseline; EADV, European Academy of Dermatology and Venereology; NRS, numeric rating scale; PSSI 90, ≥90% improvement from baseline in Psoriasis Scalp Severity Index; sPGA, static Physician Global Assessment; sPGA 0/1; sPGA score of 0 or 1; ss-PGA 0/1, scalp-specific Physician Global Assessment score of 0 or 1; TYK2, tyrosine kinase 2.
- Lebwohl M. Deucravacitinib, an oral selective tyrosine kinase 2 (TYK2) inhibitor, in patients with moderate to severe scalp psoriasis: efficacy and safety results of a phase 3b/4, multicenter, randomized, double-blinded, placebo-controlled trial (PSORIATYK SCALP). Oral Abstract #FC04.07. Presented at: European Academy of Dermatology and Venereology Congress; Sep 25–28, 2024; Amsterdam, NL.
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