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Visual abstract | Early guselkumab intervention in psoriasis leads to 'clinical super response': Week 28 results from the phase IIb GUIDE study
By Ella Dixon
Test your knowledge! Take our quick quiz before and after you read this article to find out if you improved your knowledge. Results help us to improve content and continually provide open-access education.
The Psoriasis and Psoriatic Arthritis Hub is pleased to present a visual abstract summarizing Week 28 data from the ongoing phase IIIb GUIDE study, investigating the efficacy of guselkumab in patients with moderate-severe plaque psoriasis with either a short disease duration (<2 years) and or a long disease duration (>2 years).1
Key baseline patient characteristics are shown in Table 1. The baseline mean psoriasis area and severity and dermatology life quality index scores were similar between the groups.1
Table 1. Baseline patient characteristics*
|
Characteristic, % unless otherwise stated |
SDD (N = 357) |
LDD (N = 523) |
Overall (N = 880) |
|---|---|---|---|
|
Sex |
|
|
|
|
Female |
31.9 |
27.9 |
29.5 |
|
Male |
68.1 |
72.1 |
70.5 |
|
Age at baseline, years |
|
|
|
|
<45 |
62.5 |
50.5 |
55.3 |
|
45–65 |
30.8 |
42.6 |
37.8 |
|
>65 |
6.7 |
6.9 |
6.8 |
|
Mean disease duration, years |
1.2 |
20.2 |
12.5 |
|
Mean PASI, score |
18.7 |
19.4 |
19.1 |
|
Mean DLQI, score |
19.1 |
18.9 |
19.0 |
|
Patients with prior systemic and/or biologic therapy |
24.6 |
68.3 |
50.6 |
|
DLQI, Dermatology Life Quality Index; LDD, long disease duration; PASI, Psoriasis Area and Severity Index; SDD, short disease duration. *Adapted from Schäkel, et al.1 |
|||
The results from this study have demonstrated that early intervention with guselkumab in patients with psoriasis may lead to a better clinical response, which could lead to overall better long-term outcomes for patients.1
- Schäkel K, Reich K, Asadullah K, et al. Early disease intervention with guselkumab in psoriasis leads to a higher rate of stable complete skin clearance (‘clinical super response’): Week 28 results from the ongoing phase IIIb randomized, double-blind, parallel-group, GUIDE study 2023;37(10):2016-2027. DOI: 10.1111/jdv.19236
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