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2024-10-11T13:12:12.000Z

Quality of life after tildrakizumab treatment for plaque psoriasis: Results from a phase IV study

Oct 11, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in psoriasis.

Tildrakizumab, an anti-IL-23 mAb, is approved for the treatment of moderate-to-severe plaque psoriasis in adult patients.1 A phase IV real-world, open-label, US-based study (NCT03718299) was initiated to evaluate the effect of tildrakizumab on HRQoL in patients with plaque psoriasis. A total of 55 patients were enrolled; 45 patients completed 64 weeks of treatment and were subsequently assessed. The primary endpoint was improvement in PGWBI from baseline. Changes to DLQI and safety outcomes were also assessed.1

Key learnings

Significant improvements were observed in PGWBI and DLQI. The mean PGWBI score improved over time, increasing from 78.1 at baseline to 85.2 at Week 52 (p < 0.001). Mean DLQI score improved from 9.4 to 2.0 by Week 64 (p < 0.001). 

Significant improvements were seen in the PGWBI subdomains of positive well-being and general health. Other domains, such as anxiety and depression, showed improvement trends. 

At Week 64, 62.2% of patients reported minimal or no impact of psoriasis on their QoL (DLQI 0/1). These improvements were evident from Week 4, indicating rapid and sustained benefits, with the proportion of patients achieving DLQI 0/1 increasing over time. 

Overall, tildrakizumab demonstrated long-term effectiveness in enhancing both psychological and skin-related QoL, with no adverse events reported relating to tildrakizumab treatment. This real-world evidence strengthens confidence in tildrakizumab as a treatment for improving patient-reported outcomes. 

Abbreviations: DLQI, Dermatology Life Quality Index; HRQoL, health-related quality of life; IL, interleukin; mAb, monoclonal antibody; PGWBI, Psychological General Well-Being Index; QoL, quality of life 

  1. Bhatia N, Heim J, Vasquez JG, et al. Long-term quality of life outcomes from a phase 4 study of tildrakizumab in patients with moderate- to-severe plaque psoriasis in a real-world setting. J Dermatolog Treat. 2024;35(1):2310631. DOI: 10.1080/09546634.2024.2310631

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