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2024-11-01T09:52:35.000Z

Phase III results of vunakizumab for moderate-to-severe chronic plaque psoriasis

Nov 1, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in plaque psoriasis.


Vunakizumab, a novel anti-IL-17A monoclonal antibody, was investigated in a randomized, double-blind phase III trial (NCT04839016) for treating moderate-to-severe chronic plaque psoriasis.1 The trial enrolled 690 patients, who were randomized 2:1 to receive either vunakizumab 240 mg (n = 461) or placebo (n = 229) over 12 weeks, followed by a maintenance period of up to 52 weeks. The co-primary endpoints were the proportion of patients achieving PASI 90 and a sPGA 0/1 score at Week 12.1


Key learnings
At Week 12, a higher proportion of patients treated with vunakizumab vs placebo achieved PASI 90 and sPGA 0/1 (76.8% vs 0.9% and 71.8% vs 0.4%, respectively; p<0.0001). Efficacy was maintained through Week 52 with continuous vunakizumab.
Median time to PASI 90 response was 8.3 weeks in the vunakizumab group and was not reached in the placebo group. At 12 weeks, a higher proportion of patients in the vunakizumab group showed improved HR-QoL by achieving DLQI 0/1 compared with placebo (62.0% vs 12.1%). 
The incidence of AEs in the first 12 weeks was similar between the vunakizumab and placebo groups (69.1% vs 71.6%). Serious treatment-related AEs occurred in 0.9% of patients in the vunakizumab group compared with none in the placebo group. No new safety signals were observed with continuous treatment with vunakizumab up to 52 weeks.
Vunakizumab demonstrated rapid, deep, and durable responses with favorable tolerability, offering a promising therapeutic option for chronic plaque psoriasis, comparable with other IL-17A inhibitors. The safety and efficacy of vunakizumab compared with other approved therapies for psoriasis require further investigation.

Abbreviations: AE, adverse event; DLQI, dermatology life quality index; HR-QoL, health-related quality of life; IL, interleukin; PASI 90, 90% improvement in Psoriasis Area and Severity Index; sPGA, Static Physician's Global Assessment. 

  1. Yan K, Li F, Bi X, et al. Efficacy and safety of vunakizumab in moderate-to-severe chronic plaque psoriasis: A randomized, double-blind, placebo-controlled phase 3 trial. J Am Acad Dermatol. 2024. Online ahead of print. DOI: 1016/j.jaad.2024.09.031

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