All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a healthcare professional.
The PsOPsA Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy
Introducing
Now you can personalise
your PsOPsA Hub experience!
Bookmark content to read later
Select your specific areas of interest
View content recommended for you
Find out moreThe PsOPsA Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the PsOPsA Hub cannot guarantee the accuracy of translated content. The PsOPsA Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.
The PsOPsA Hub is supported by educational grants. All educational content is developed independently by SES in collaboration with our expert steering committee, with no input or influence from financial supporters. We would like to express our gratitude to the following companies for their support: • UCB: For website development, launch, and ongoing maintenance. • UCB: For educational content and news updates.
Outcomes in patients with psoriasis after treatment with biologics for ≥10 consecutive years
By Ella Dixon
|
Biologic treatments have improved outcomes in patients with psoriasis, but data on patient and treatment characteristics and outcomes in long-term users are limited. A study published by Henckens et al. in Clinical and Experimental Dermatology explored data from patients who had received continuous treatment with the same biologic for ≥10 years (ultra-long biologic users; N = 118). Data were gathered from the BioCAPTURE multicenter registry (N = 1,377) which included patients in the Netherlands with psoriasis who received treatment with biologics or small-molecule inhibitors. The highest proportion of ultra-long users received ustekinumab (37.1%), followed by adalimumab (24.2%), etanercept (14.8%), and infliximab (6.3%). |
| Key learnings |
| 66.1% of ultra-long users did not require additional systemic antipsoriatic treatment. Dose adjustments were common; 40.7% of patients required dose reductions, 29.7% required escalations, and 13.6% of patients required both. 69.5% of patients had at least one comorbidity. |
| The median PASI score decreased from 11.4 at the start of treatment to 2.7 at Month 6, remaining stable throughout subsequent treatment at a score of ≤3. Complete clearance (PASI 100) was rare, in 3.9% of patients at Month 6. |
| 62.3% of patients remained on the same biologic after 15 years. Discontinuation reasons included loss of efficacy (9.3%) and adverse events (7.6%; lung cancer, AML, and heart failure). |
| This study demonstrates that long-term biologic use is feasible even in patients with multiple comorbidities, and provides clinicians with important evidence on ultra-long treatment with biologics. |
Abbreviations: AML, acute myeloid leukemia; PASI, Psoriasis Area and Severity Index.
- Henckens N, Otero ME, van den Reek J, et al. Revealing patient characteristics and treatment outcomes among ultra-long users of biologics for psoriasis. Clin Exp Dermatol. 2025;50(2):348-356. DOI: 1093/ced/llae333
More about...
Newsletter
Subscribe to get the best content related to Psoriasis and Psoriatic Arthritis delivered to your inbox