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2024-11-29T09:34:59.000Z

Efficacy and safety of JNJ-77242113 in patients with moderate-to-severe psoriasis: Long-term extension FRONTIER-2 trial

Nov 29, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in psoriasis.


In the phase IIb FRONTIER-1 trial (NCT05223868), JNJ-77242113, an oral IL-23 inhibitor, improved response rates vs placebo at Week 16 in patients with moderate-to-severe plaque psoriasis.1 The FRONTIER-2 trial (NCT05364554) assessed the safety and efficacy of JNJ-77242113 through to Week 52 in 227 patients who completed FRONTIER-1.1 Results from this trial were published in the Journal of the American Academy of Dermatology by Ferris et al.1


Key learnings
At Week 52, 49%, 58%, 70%, 65%, 76%, and 66% of patients achieved a PASI 75 response in 25 mg QD, 25 mg BID, 50 mg QD, 100 mg QD, 100 mg BID, and placebo→100 mg QD groups, respectively.
The proportion of patients achieving PASI 90, PASI 100, IGA 0/1, and IGA 0 responses at Week 16 were generally maintained through Week 52, with the highest response rates in the higher dose groups.
Improvements in PRO measures at Week 16 were maintained through Week 52, and no new safety signals were observed.
Results from this trial demonstrate that the improvements in clinical and PRO measures with JNJ-77242113 at Week 16 were durable through Week 52 with no new safety signals, and patients switching from placebo to JNJ-77242113 100 mg QD experienced rapid improvements in response rates. Abbreviations: MDA, minimal disease activity; PsA, psoriatic arthritis.

Abbreviations: BID, twice daily; IGA, Investigator’s Global Assessment; IL, interleukin; LTE, long-term extension; PASI, Psoriasis Area and Severity Index; PRO, patient-reported outcomes; QD, once daily.

  1. Ferris LK, Bagel H, Huang YH, et al. FRONTIER-2: A phase 2b, long-term extension, dose-ranging study of oral JNJ-77242113 for the treatment of moderate-to-severe plaque psoriasis. J Am Acad Dermatol. Online ahead of print. DOI: 10.1016/j.jaad.2024.10.076

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