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2024-11-18T16:06:45.000Z

REZPEG in the treatment of plaque psoriasis: Results from a phase Ib trial

Nov 18, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in psoriasis.

In inflammatory diseases such as psoriasis, Tregs are impaired and there is limited evidence on the therapeutic potential of Treg restoration.1 REZPEG selectively expands CD25bright regulatory T cells without increasing conventional T cells, suggesting it restores immune tolerance and balances immune responses, which are dysregulated in psoriasis.1

A phase Ib randomized, placebo-controlled study (NCT04119557) published in Nature Communicationsinvestigated REZPEG in 30 patients with chronic plaque psoriasis for 12 weeks, with follow-up to 19 weeks. Responders at Week 19 had follow-up through Week 48.

Key learnings
Patients treated with REZPEG showed a LS mean improvement from baseline in PASI scores compared with placebo at Week 12 and Week 19 (44.5% vs 26.2% and 51.4% vs 19.9%, respectively), demonstrating sustained efficacy. 
REZPEG was well tolerated, with TEAEs reported by 70.8% of patients. All except one TEAE were of mild-to-moderate severity, and no serious adverse events were reported. Injection site reactions were the most common treatment-related side effects. 
REZPEG treatment led to long-term, treatment-free disease control, with a sustained decrease in psoriasis symptoms, highlighting the potential of REZPEG in providing prolonged remission and reducing treatment burden. 
REZPEG has the potential to be an alternative to existing therapies for psoriasis, particularly for patients with inadequate responses to current biologics or immunosuppressants. 

Abbreviations: LS, least-squares; PASI, Psoriasis Area and Severity Index; REZPEG, rezpegaldesleukin; TEAE, treatment-emergent adverse event; Tregs, regulatory T cells. 

  1. Silverberg JI, Rosmarin D, Chovatiya R, et al. The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials. Nat Commun. 2024;15(1):9230. DOI: 1038/s41467-024-53384-1

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