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REZPEG in the treatment of plaque psoriasis: Results from a phase Ib trial
By Ella Dixon
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In inflammatory diseases such as psoriasis, Tregs are impaired and there is limited evidence on the therapeutic potential of Treg restoration.1 REZPEG selectively expands CD25bright regulatory T cells without increasing conventional T cells, suggesting it restores immune tolerance and balances immune responses, which are dysregulated in psoriasis.1 A phase Ib randomized, placebo-controlled study (NCT04119557) published in Nature Communicationsinvestigated REZPEG in 30 patients with chronic plaque psoriasis for 12 weeks, with follow-up to 19 weeks. Responders at Week 19 had follow-up through Week 48.
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| Key learnings |
| Patients treated with REZPEG showed a LS mean improvement from baseline in PASI scores compared with placebo at Week 12 and Week 19 (44.5% vs 26.2% and 51.4% vs 19.9%, respectively), demonstrating sustained efficacy. |
| REZPEG was well tolerated, with TEAEs reported by 70.8% of patients. All except one TEAE were of mild-to-moderate severity, and no serious adverse events were reported. Injection site reactions were the most common treatment-related side effects. |
| REZPEG treatment led to long-term, treatment-free disease control, with a sustained decrease in psoriasis symptoms, highlighting the potential of REZPEG in providing prolonged remission and reducing treatment burden. |
| REZPEG has the potential to be an alternative to existing therapies for psoriasis, particularly for patients with inadequate responses to current biologics or immunosuppressants. |
Abbreviations: LS, least-squares; PASI, Psoriasis Area and Severity Index; REZPEG, rezpegaldesleukin; TEAE, treatment-emergent adverse event; Tregs, regulatory T cells.
- Silverberg JI, Rosmarin D, Chovatiya R, et al. The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials. Nat Commun. 2024;15(1):9230. DOI: 1038/s41467-024-53384-1
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