All content on this site is intended for healthcare professionals only. By acknowledging this message and accessing the information on this website you are confirming that you are a healthcare professional.

The PsOPsA Hub uses cookies on this website. They help us give you the best online experience. By continuing to use our website without changing your cookie settings, you agree to our use of cookies in accordance with our updated Cookie Policy

Introducing

Now you can personalise
your PsOPsA Hub experience!

Bookmark content to read later

Select your specific areas of interest

View content recommended for you

Find out more
  TRANSLATE

The PsOPsA Hub website uses a third-party service provided by Google that dynamically translates web content. Translations are machine generated, so may not be an exact or complete translation, and the PsOPsA Hub cannot guarantee the accuracy of translated content. The PsOPsA Hub and its employees will not be liable for any direct, indirect, or consequential damages (even if foreseeable) resulting from use of the Google Translate feature. For further support with Google Translate, visit Google Translate Help.

Steering CommitteeAbout UsNewsletterContact
LOADING
You're logged in! Click here any time to manage your account or log out.
LOADING
You're logged in! Click here any time to manage your account or log out.
2024-05-17T15:06:30.000Z

PsoBest registry: Real-world outcomes of brodalumab for psoriasis and PsA

May 17, 2024
Share:
Learning objective: After reading this article, learners will be able to cite a new clinical development in psoriatic disease. 

Bookmark this article

Brodalumab, an anti-interleukin 17 monoclonal antibody, is approved for use in adults with moderate-to-severe plaque psoriasis and has shown efficacy vs placebo for patients with psoriatic arthritis (PsA). However, there is a lack of real-world evidence for the safety and efficacy of brodalumab. 

Here, we summarize an interim analysis by Schaeffer et al.1 published in Journal of Dermatological Treatment on the real-world outcomes of brodalumab in psoriatic disease from the German psoriasis registry PsoBest. 

Methods1 

  • The German psoriasis registry PsoBest, follows adult patients with moderate-to-severe psoriasis treated with systemic non-biologic or biologic treatment for the first time.  

  • In this analysis, patients who were monitored for at least 12 months were selected (data cutoff June 30, 2021). 

  • When selecting patients who had started brodalumab treatment (210mg every 2 weeks), an analysis set of 227 patients was defined. 

  • The Psoriasis Area and Severity Index (PASI) was used to measure clinical response.  

  • The Dermatology Life Quality Index and Patient Benefit Index (PBI) were used to collect patient-reported outcomes. 

Key findings1 

  • Of the analysis cohort, 189 patients had psoriasis and 38 had PsA. Most patients were male (69.2%), with a mean disease duration of 22 years, and a baseline mean PASI of 18.0. 

  • Within the observation period, 18.1% of patients discontinued treatment. 

    • The mean time to discontinuation of brodalumab was 8.0 months for patients with psoriasis and 9.7 months for patients with PsA. 

    • The most common reason for discontinuation was lack or loss of effectiveness (Figure 1A). 

  • Mean PASI decreased from baseline to 12 months (18.0 to 2.3).  

  • Mean Patient Benefit Index was maintained from 3 months to 12 months (3.0 to 3.1).  

  • Mean Dermatology Life Quality Index decreased from baseline to 12 months (12.5 to 1.4, Figure 1B). 

  • The mean drug survival rates were 96.6%, 86.4%, and 76.2% at 3, 6 and 12 months, respectively. 

Figure 1. A Reasons for discontinuation of brodalumab and B mean DLQI from baseline to 12 months* 

DLQI, Dermatology Life Quality Index;PsA, psoriatic arthritis; PsO, psoriasis. 

*Data from Schaeffer, et al.1 

 

Key learnings 

  • Clinical and patient-reported outcomes in this analysis suggest that first-time treatment with brodalumab leads to rapid efficacy and a positive impact on quality of life, which is maintained up to 12 months.  

  • Mean time to treatment discontinuation and drug survival rates indicate high treatment sustainability with brodalumab. 

  1. Schaeffer L, Ben-Anaya N, Sorbe C, et al. Real-world outcomes and drug survival of brodalumab: results from the German Psoriasis Registry PsoBest. J Dermatolog Treat. 2024;35(1):2340107. DOI: 10.1080/09546634.2024.2340107 

Newsletter

Subscribe to get the best content related to Psoriasis and Psoriatic Arthritis delivered to your inbox