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PsoBest registry: Real-world outcomes of brodalumab for psoriasis and PsA

May 17, 2024
Learning objective: After reading this article, learners will be able to cite a new clinical development in psoriatic disease. 

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Brodalumab, an anti-interleukin 17 monoclonal antibody, is approved for use in adults with moderate-to-severe plaque psoriasis and has shown efficacy vs placebo for patients with psoriatic arthritis (PsA). However, there is a lack of real-world evidence for the safety and efficacy of brodalumab. 

Here, we summarize an interim analysis by Schaeffer et al.1 published in Journal of Dermatological Treatment on the real-world outcomes of brodalumab in psoriatic disease from the German psoriasis registry PsoBest. 


  • The German psoriasis registry PsoBest, follows adult patients with moderate-to-severe psoriasis treated with systemic non-biologic or biologic treatment for the first time.  

  • In this analysis, patients who were monitored for at least 12 months were selected (data cutoff June 30, 2021). 

  • When selecting patients who had started brodalumab treatment (210mg every 2 weeks), an analysis set of 227 patients was defined. 

  • The Psoriasis Area and Severity Index (PASI) was used to measure clinical response.  

  • The Dermatology Life Quality Index and Patient Benefit Index (PBI) were used to collect patient-reported outcomes. 

Key findings1 

  • Of the analysis cohort, 189 patients had psoriasis and 38 had PsA. Most patients were male (69.2%), with a mean disease duration of 22 years, and a baseline mean PASI of 18.0. 

  • Within the observation period, 18.1% of patients discontinued treatment. 

    • The mean time to discontinuation of brodalumab was 8.0 months for patients with psoriasis and 9.7 months for patients with PsA. 

    • The most common reason for discontinuation was lack or loss of effectiveness (Figure 1A). 

  • Mean PASI decreased from baseline to 12 months (18.0 to 2.3).  

  • Mean Patient Benefit Index was maintained from 3 months to 12 months (3.0 to 3.1).  

  • Mean Dermatology Life Quality Index decreased from baseline to 12 months (12.5 to 1.4, Figure 1B). 

  • The mean drug survival rates were 96.6%, 86.4%, and 76.2% at 3, 6 and 12 months, respectively. 

Figure 1. A Reasons for discontinuation of brodalumab and B mean DLQI from baseline to 12 months* 

DLQI, Dermatology Life Quality Index;PsA, psoriatic arthritis; PsO, psoriasis. 

*Data from Schaeffer, et al.1 


Key learnings 

  • Clinical and patient-reported outcomes in this analysis suggest that first-time treatment with brodalumab leads to rapid efficacy and a positive impact on quality of life, which is maintained up to 12 months.  

  • Mean time to treatment discontinuation and drug survival rates indicate high treatment sustainability with brodalumab. 

  1. Schaeffer L, Ben-Anaya N, Sorbe C, et al. Real-world outcomes and drug survival of brodalumab: results from the German Psoriasis Registry PsoBest. J Dermatolog Treat. 2024;35(1):2340107. DOI: 10.1080/09546634.2024.2340107 


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