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PsoBest registry: Real-world outcomes of brodalumab for psoriasis and PsA
Brodalumab, an anti-interleukin 17 monoclonal antibody, is approved for use in adults with moderate-to-severe plaque psoriasis and has shown efficacy vs placebo for patients with psoriatic arthritis (PsA). However, there is a lack of real-world evidence for the safety and efficacy of brodalumab.
Here, we summarize an interim analysis by Schaeffer et al.1 published in Journal of Dermatological Treatment on the real-world outcomes of brodalumab in psoriatic disease from the German psoriasis registry PsoBest.
Methods1
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The German psoriasis registry PsoBest, follows adult patients with moderate-to-severe psoriasis treated with systemic non-biologic or biologic treatment for the first time.
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In this analysis, patients who were monitored for at least 12 months were selected (data cutoff June 30, 2021).
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When selecting patients who had started brodalumab treatment (210 mg every 2 weeks), an analysis set of 227 patients was defined.
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The Psoriasis Area and Severity Index (PASI) was used to measure clinical response.
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The Dermatology Life Quality Index and Patient Benefit Index (PBI) were used to collect patient-reported outcomes.
Key findings1
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Of the analysis cohort, 189 patients had psoriasis and 38 had PsA. Most patients were male (69.2%), with a mean disease duration of 22 years, and a baseline mean PASI of 18.0.
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Within the observation period, 18.1% of patients discontinued treatment.
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The mean time to discontinuation of brodalumab was 8.0 months for patients with psoriasis and 9.7 months for patients with PsA.
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The most common reason for discontinuation was lack or loss of effectiveness (Figure 1A).
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Mean PASI decreased from baseline to 12 months (18.0 to 2.3).
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Mean Patient Benefit Index was maintained from 3 months to 12 months (3.0 to 3.1).
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Mean Dermatology Life Quality Index decreased from baseline to 12 months (12.5 to 1.4, Figure 1B).
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The mean drug survival rates were 96.6%, 86.4%, and 76.2% at 3, 6 and 12 months, respectively.
Figure 1. A Reasons for discontinuation of brodalumab and B mean DLQI from baseline to 12 months*
DLQI, Dermatology Life Quality Index; PsA, psoriatic arthritis; PsO, psoriasis.
*Data from Schaeffer, et al.1
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Key learnings |
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References
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