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2024-07-19T10:42:56.000Z

Guselkumab vs fumaric acid esters for plaque psoriasis: Results from POLARIS trial

Jul 19, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in psoriasis.

Results from the phase III POLARIS trial, comparing guselkumab (GUS) with fumaric acid esters (FAE) in systemic treatment-naïve patients with moderate-to-severe plaque psoriasis, have been published in British Journal of Dermatology by Thaci et al.1 The trial assessed long-term safety and efficacy of GUS, as well as the durability of responses after stopping GUS treatment.1

Key learnings:

At Week 32, 78% and 90% of patients treated with GUS achieved 75% improvement in Psoriasis Area and Severity Index (PASI 75) and PASI 90, compared with 12% and 24% of FAE-treated patients, respectively.

At Week 56, 91% of GUS-treated patients maintained PASI 90 response vs 50% of FAE-treated patients. PASI 90 response was also achieved by 80% of patients who switched from FAE to GUS at Week 32.

47% of GUS-GUS withdrawal patients and 25% of FAE-GUS withdrawal patients maintained a PASI score ≤5 at Week 100.

Incidence of adverse events and treatment discontinuation was lower in both the GUS and switched to GUS groups compared with the FAE group.
In this study, GUS demonstrated superior long-term efficacy and safety compared with FAE for systemic treatment-naïve patients, suggesting potential as a preferred first-line systemic therapy.


  1. Thaçi D, Pinter A, Sebastian M, et al. Guselkumab demonstrates long-term efficacy and maintenance of treatment response postwithdrawal in systemic treatment-naïve patients and nonresponders to fumaric acid esters: results from parts II and III of a randomized active-comparator-controlled phase IIIb trial (POLARIS). Br J Dermatol. 2024;191:36-48. DOI: 10.1093/bjd/ljad523

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