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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
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Certolizumab safety and efficacy in clinical practice
By Ella Dixon
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A retrospective, multicenter, observational study of certolizumab pegol treatment in patients with plaque psoriasis has been published in the International Journal of Dermatology by Sahuquillo-Torralba et al.1 A total of 67 patients were evaluated in the study and were observed from the first dose of certolizumab until the date of the first missed dose.1 |
| Key learnings: |
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Absolute PASI <3 was achieved in 69%, 86%, and 92% of patients receiving certolizumab at Weeks 12, 24, and 52, respectively, with a drug survival rate of 85% in the first year. |
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21% of patients discontinued certolizumab, the majority due to lack/loss of effectiveness. |
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In 14 patients who initiated treatment during pregnancy and/or lactation, there were no recorded adverse events at the time of delivery or in the neonatal period, supporting guidelines that recommend the use of certolizumab as a first-line choice of biologic for patients planning pregnancy or breastfeeding. |
- Sahuquillo-Torralba A, Mansilla-Polo M, Pujol-Marco C, et al. Certolizumab pegol effectiveness, survival and safety in patients with psoriasis: A multicenter retrospective analysis in daily clinical practice by the Spanish Psoriasis Group. Int J Dermatol. 2024. Online ahead of print. DOI: 10.1111/ijd.17238
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