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Biomarkers associated with response in PsA: A phase II trial of deucravacitinib
By Ella Dixon
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Deucravacitinib, a TYK2 inhibitor, has demonstrated efficacy in both PsO and PsA, and is approved in multiple countries for adult patients with plaque PsO.1 An analysis of a phase II trial of deucravacitinib, which evaluated biomarker association with disease activity, pharmacodynamics, and clinical responses, was published in Arthritis and Rheumatology by FitzGerald et al.1 A total of 203 patients with PsA were assigned 1:1:1 to deucravacitinib 6 mg, deucravacitinib 12 mg, or placebo. Biomarkers, including those associated with the IL-23 pathway, and clinical responses, including PASI 75 and ACR 20, were assessed at Week 16.1 |
| Key learnings |
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Elevated serum levels of IL-17A, BD-2, and IL-19 were significantly associated with higher baseline disease activity in PsA, including skin disease severity as measured by PASI. |
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Deucravacitinib treatment significantly reduced levels of IL-17A, BD-2, IL-19, and other inflammatory biomarkers by Week 16, indicating suppression of inflammatory pathways. |
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Patients with higher baseline levels of IL-23 pathway-associated biomarkers were more likely to achieve clinical improvement after deucravacitinib treatment, as evidenced by PASI 75 and ACR 20 responses. |
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This study suggests that assessing IL-23 pathway-associated biomarkers could guide therapeutic decisions in PsA, identifying patients who might benefit most from deucravacitinib and allow for personalized therapy. |
Abbreviations: ACR 20, 20% improvement in American College of Rheumatology response; BD2, β-defensin 2; IL, interleukin; PASI 75, 75% improvement in Psoriasis Area and Severity Index; PsA, psoriatic arthritis; PsO, psoriasis; TYK2, tyrosine kinase 2.
- FitzGerald O, Gladman D, Mease P, et al. Phase 2 Trial of Deucravacitinib in Psoriatic Arthritis: Biomarkers Associated With Disease Activity, Pharmacodynamics, and Clinical Responses. Arthritis Rheumatol. 2024;76(9):1397-1407. DOI: 10.1002/art.42921
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